Workgroup Prof. Ziegler

Magnetic Force Microscopy. This technique, known as MFM for short, is one of many standard modes that you can perform with Asylum AFMs. You can use it to map the magnetic signal or the distribution of magnetic domains of an appropriate sample. MFM is a 2-pass technique where every scan line is actually scanned twice. In the first pass, the tip Scans the surface as it would in regular AC mode. In the second pass, referred to as the Nap pass, the tip lifts above the surface by a constant height and images the longer-range magnetic forces along that same scan line.

Molecular Force Probe (MFP)

The Molecular Force Probe (MFP) is a single-axis force curve tracer.
The device uses a small flexible cantilever that deflects in response
to forces between the cantilever tip and a sample. When a single
molecule is tethered between the tip and sample, the MFP acts as a
nanoscale elasticity measurement device. This allows, for example,
the measurement of the force required to mechanically unfold a
single protein.

basic MFP system models:

The MFP-IO (Inverted Optical) operates on the top of an inverted
optical microscope. This allows high-resolution optical
imaging and epi-fluorescence measurements to be made
simultaneously with force measurements.
The MFP-IO replaces the sample stage of the commercial microscope
with a mechanical stage allowing sub-micron positioning of the
sample in two dimensions. This stage is called the MFP-IO baseplate.

The MFP-SA (standalone) is a standalone
instrument that uses the same head as the
MFP-IO. However, instead of operating on
a commercial optical microscope, the MFPSA
operates on its own standalone base.
This base includes a two dimensional submicron
mechanical stage for positioning
the sample as well as an inverted video
microscope with two magnifications for
viewing the sample and tip.
The MFP-SA provides a much smaller
footprint and higher immunity to external

---------measurement under fluid??? s45

Designed specifically for researchers, the MFP is ideal for those
working in bioscience, polymers, biomaterials. Applications for the
MFP include:
? Molecular elasticity
? Protein folding
? Chemical sensing
? Polymers
? DNA Interatomic/Molecular bonds
? Ligand-receptor bonds
? Covalent bonds
? Colloidal forces
? Van der Waals forces
? Hydration forces
? Hydrophobic forces
? Adhesion
? Energy dissipation

-------background on how the MFP system works
-bild s.58

s.68   ff



Zum Seitenanfang